p57 in Hydatidiform Moles: Evaluation of Antibodies and Expression in Various Cell Types
نویسندگان
چکیده
منابع مشابه
p57 kip2 immunohistochemistry: ancillary technique in hydatidiform moles diagnosis
Background Gestational trophoblastic disease is a group of benign and malignant entities, where the hydatidiform mole is the most common, and can be divided into complete hydatidiform mole and partial hydatidiform mole. However, the histological criteria are still questionable and also, histologic evaluation alone is prone to great interobserver variability. In this way, inmunohistochemical ana...
متن کاملDiagnosis of hydatidiform moles using p57 immunohistochemistry and HER2 fluorescent in situ hybridization.
Fluorescent in situ hybridization (FISH) for HER2 performed on paraffin-embedded tissue samples and immunohistochemical analysis for p57 may be useful ancillary studies to aid in the diagnosis and classification of hydatidiform moles (HMs). HER2 FISH was validated against 24 paraffin-embedded sections of HMs and hydropic abortions and showed an 85% concordance rate. A morphologic assessment bas...
متن کاملTetraploidy in hydatidiform moles.
STUDY QUESTION How does tetraploidy develop in hydatidiform moles (HMs), and what is the frequency of the different origins? SUMMARY ANSWER Most molar pregnancies with tetraploid cells appear to be produced by somatic endoreduplications, while a minority originate from a tetraploid zygote. The frequency of zygotic tetraploidy was estimated to be 0.7%. WHAT IS KNOWN ALREADY The parental orig...
متن کاملki-۶۷ expression in hydatidiform moles and hydropic abortions
conclusions despite the significant differences , ki-67 immunostaining could not be helpful in distinguishing molar placentas from hydropic abortions as well as partial from complete hydatidiform moles, because there are considerable overlaps between results in different categories. objectives this study was undertaken to determine whether the expression of ki-67 protein could differentiate the...
متن کاملKi-67 Expression in Hydatidiform Moles and Hydropic Abortions
BACKGROUND Differential diagnosis of hydatidiform moles from non-molar specimens as well as their sub-classification such as complete and partial hydatidiform moles are important for clinical management and accurate risk assessment for persistent gestational trophoblastic disease, but diagnosis based solely on histomorphology suffers from poor interobserver and intraobserver reproducibility. ...
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ژورنال
عنوان ژورنال: Applied Immunohistochemistry & Molecular Morphology
سال: 2019
ISSN: 1541-2016
DOI: 10.1097/pai.0000000000000807